Can head shape influence Alzheimer’s disease pathology? (Alzheimer’s & Dementia)
The newly launched AD-Smart Alzheimer’s disease platform trial will test repurposed drugs in the U.K., starting with the diabetes drug metformin and the attention deficit-hyperactivity disorder (ADHD) agent atomoxetine (Strattera).
Data from mice and human brains showed links between levels of the enzyme PLA2G2F and cognitive resilience. (Nature Neuroscience)
Black participants in a cohort study had a delayed age of mean amyloid onset compared with white participants, which may partly explain why Black adults have a higher prevalence of dementia but a lower prevalence of amyloid positivity. (JAMA Network Open)
The percentage of 8-year-old autistic children who met criteria for profound autism was 16.5% using an updated definition, considerably lower than with the prior definition. (Journal of the American Academy of Child & Adolescent Psychiatry)
In a randomized trial, use of prenatal phosphatidylcholine supplements decreased social withdrawal problems and increased IQ test performance in offspring through age 4, but did not reduce attention problems. (American Journal of Obstetrics and Gynecology)
Cross-sectional analyses showed that transient ischemic attack care in the emergency department shifted from inpatient admission to comprehensive outpatient evaluation between 2013 and 2021. (JAMA Neurology)
Platelet count polygenic scores may influence how aspirin might prevent dementia, suggesting that certain subgroups of older adults may benefit, ASPREE trial data suggested. (Alzheimer’s & Dementia)
An online intervention reduced seizure frequency and anxiety in adults with functional seizures in a randomized trial in Australia. (JAMA Neurology)
A small functional MRI study suggested that long COVID cognitive fatigue was related to decreased cerebral blood flow and sustained attention. (NeuroImage: Reports)
The Washington Post looked at how the Mayo Clinic’s Ron Petersen, MD, PhD, a top dementia expert, keeps his brain healthy at age 80.
