Could GLP-1 Drugs Replace Current PMOS Treatments?
In short, no. Even if a GLP-1 or similar medication is eventually approved for the treatment of PMOS, it likely would not be a stand-alone therapy. A GLP-1 may not adequately control androgens or regulate menses, for example, or sufficiently improve fertility in all patients.
When it comes to lifestyle and nutrition changes, there is always a place for healthy habits in PMOS treatment, whether you are taking a GLP-1 or not, says Christa Brown, RDN, a dietitian in private practice in Woodbridge, New Jersey, who specializes in PMOS care as well as support for those on a GLP-1 medication. Nutrition habits like consistent fiber and protein intake to promote insulin sensitivity, exercise in the form of resistance training, adequate sleep, and stress management are all areas she focuses on when working with women who have PMOS.
“The biggest [lifestyle factor where] I see room for opportunity is resistance-based strength training,” Brown says. “That muscle growth supports reducing insulin resistance.”
There are many things to consider when treating PMOS. While weight reduction may be one part, it is not the only therapy. “We still need to treat common symptoms like excess hair growth and acne,” says Schon. “Weight reduction can help, but it’s still one piece of overall care.”
“PMOS is a lifelong reproductive disorder, but treatment goals may vary at different points throughout the reproductive lifespan,” she says. “We have to take all of these things into consideration when identifying the right treatments for patients.”
