If you’re wondering what Clooney has to do with Wyle’s big moment, let’s take a trip down memory lane.
The two actors played doctors on the hit medical drama ER, which ran for 15 seasons from 1994 to 2009. Wyle portrayed Dr. John Carter, while Clooney played Dr. Doug Ross. Clooney was named Sexiest Man Alive in 1997 and again in 2006, making Wyle’s new title a full-circle moment for fans who remember their days on the show.
Wyle has since found renewed success playing Dr. Robby on The Pitt, earning back-to-back best actor Emmy wins in 2025 and 2026. Before his latest career resurgence, he earned five consecutive Primetime Emmy nominations from 1995 to 1999 for his breakout supporting role on ER.
